ARMET is a Soluble ER Protein Induced by the Unfolded Protein Response via ERSE-II Element

• DOI: 10.1247/csf.07001
• Publication Date: 2007-07-30T05:51:16Z
• Authors: Naomi Mizobuchi; Jun Hoseki; Hiroshi Kubota; Shinya Toyokuni; Jun-ichi Nozaki; Motoko Naitoh; Akio Koizumi; Kazuhiro Nagata
• Keywords: 0301 basic medicine; BALB 3T3 Cells; Base Sequence; Molecular Sequence Data; Proteins; Endoplasmic Reticulum; Response Elements; Cell Line; Mice; 03 medical and health sciences; Gene Expression Regulation; Solubility; Animals; Amino Acid Sequence; Nerve Growth Factors; Promoter Regions, Genetic; Endoplasmic Reticulum Chaperone BiP

Arginine rich, mutated in early stage of tumors (ARMET) was first identified as a human gene highly variety cancers. However, little is known about the characteristics ARMET protein and its expression. We upregulated by endoplasmic reticulum (ER) stress. Here, we show that mouse homologue an 18-kDa soluble ER mature after cleavage signal sequence has four intramolecular disulfide bonds, including two CXXC sequences. stress stimulated expression, expression patterns mRNA tissues were similar to those Grp78, Hsp70-family required for quality control proteins ER. A reporter assay using promoter revealed unfolded response regulated ERSE-II element whose identical HERP gene. second fully characterized ERSE-II-dependent likely contributes