Optically Active Antifungal Azoles. II. Synthesis and Antifungal Activity of Polysulfide Derivatives of (2R,3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol.
1,2,4-Triazole
Triazole
Sodium methoxide
Polysulfide
DOI:
10.1248/cpb.41.1043
Publication Date:
2011-12-08T04:42:42Z
AUTHORS (6)
ABSTRACT
In an effort to find potent antifungal agents, optically active sulfur-containing triazole derivatives, sulfides (3) and sulfonamides (4), were prepared evaluated for activity against Candida albicans in vitro vivo. The by the reaction of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl )-2-butanol (1) with various heteroarylmethyl chlorides presence sodium methoxide. (4) synthesized starting from disulfide (15) three steps including oxidation corresponding sulfenamides (17). Some derivatives (3, 4) showed strong protective effects candidosis mice.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (0)
CITATIONS (13)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....