2″,4″-<i>O</i>-Diacetylquercitrin, a Novel Advanced Glycation End-Product Formation and Aldose Reductase Inhibitor from <i>Melastoma sanguineum</i>

• DOI: 10.1248/cpb.c12-00877
• Publication Date: 2013-06-01T04:12:47Z
• Authors: Ik-Soo Lee; Il Soon Kim; Yun Mi Lee; Youngseop Lee; Joo-Hwan Kim; Jin Sook Kim
• Keywords: Advanced glycation end-product

A new flavonoid, 2,″4″-O-diacetylquercitrin (1), along with six known flavonoids (2–7) were isolated from the aerial parts of Melastoma sanguineum. The structure flavonoid was established by extensive spectroscopic studies and chemical evidence. inhibitory effects compounds (1–7) on advanced glycation end-products (AGEs) formation rat lens aldose reductase (RLAR) in vitro examined. Of tested compounds, compound 1 strongest inhibitor AGEs, an IC50 11.46±0.44 µm. In RLAR assay, all exhibited greater than that a positive control, 3,3-tetramethyleneglutaric acid (IC50=28.8±1.5 µm); RLAR-inhibitory activity, 0.077±0.003