Improvement of Pharmaceutical Properties of Isoprenoid Compounds through the Formation of Cyclodextrin Pseudorotaxane-Like Supramolecules

• DOI: 10.1248/cpb.c15-00931
• Publication Date: 2016-02-04T22:23:20Z
• Authors: Taishi Higashi; Haruki Tanaka; Ayumi Yoshimatsu; Haruna Ikeda; Kanako Arima; Masatoshi Honjo; Chihiro Iwamoto; Keiichi Motoyama; Hidetoshi Arima
• Keywords: Squalene

The purpose of this study was to design cyclodextrin (CyD)-based pseudorotaxane-like supramolecular complexes with various isoprenoid compounds, such as reduced coenzyme Q10 (R-CoQ10), squalene, tocotrienol, and teprenone, evaluate their pharmaceutical properties. Squalene, teprenone formed precipitates β-CyD γ-CyD in aqueous solution, whereas R-CoQ10 solution. results powder X-ray diffraction (1)H-NMR analyses indicated that these are derived from complexes. photostability markedly improved by complexation CyDs, especially the system. In addition, dispersion rates system were higher than those system, compared corresponding physical mixtures. conclusion, properties compounds formation and/or γ-CyD.