Rational Design of Amphipathic Antimicrobial Peptides with Alternating L-/D-Amino Acids That Form Helical Structures

• DOI: 10.1248/cpb.c23-00465
• Publication Date: 2024-01-31T22:17:33Z
• Authors: Motoharu Hirano; Hidetomo Yokoo; Nobumichi Ohoka; Takahito Ito; Takashi Misawa; Makoto Oba; Takao Inoue; Yosuke Demizu
• Keywords: Gramicidin S; Cationic polymerization

Antimicrobial peptides (AMPs) are promising therapeutic agents against bacteria. We have previously reported an amphipathic AMP Stripe composed of cationic L-Lys and hydrophobic L-Leu/L-Ala residues, exhibited potent antimicrobial activity Gram-positive Gram-negative Gramicidin A (GA), repeating sequences L- D-amino acids, has a unique β