Preparation and Evaluation of Clarithromycin Taste-Masking Dry Suspension Using Hot Melt Extrusion Based on Solid Dispersion Technology

• DOI: 10.1248/cpb.c24-00206
• Publication Date: 2024-07-16T22:10:31Z
• Authors: Tianao Zhang; Min Yu; Yong Fan; Lingyang Wang; Lu Yuan; Yong Sun
• Keywords: Suspension

Clarithromycin (CLA) is the preferred drug for treating respiratory infections in pediatric patients, but it has drawbacks of extreme bitterness and poor water solubility. The purpose this study was to improve solubility mask CLA. We use Hot Melt Extrusion (HME) convert CLA Eudragit