Relationship Between Physical Activity And 6-minute Walk Distance In Patients With Pulmonary Arterial Hypertension

• DOI: 10.1249/01.mss.0000478600.24743.d5
• Publication Date: 2016-07-14T15:12:09Z
• Authors: Amanda K. Rounds
• Keywords: Regimen; Aerobic Exercise

Evidence has been presented (Mainguy et al, 2011) that the distance walked (6MWD) on 6-minute walk test (6MWT) is a surrogate measure for engagement in physical activity patients who have pulmonary hypertension (PH). PURPOSE: To determine if relationship between 6MWD and sustained following aerobic exercise training. METHODS: 20 with PH (18 women age=54.3±10.5 yrs, BMI=33±6.9 Kg/m2; 2 male age=60.0±18.4 BMI=41.5±3.5 Kg/m2), were enrolled NIH Exercise Therapy Advanced Lung Disease Trials (ClinicalTRials.gov # NCT00678821), completed 10-week supervised training regimen (target heart rate = 70-78% reserve, 30-45 min, 3 x week). Triaxial accelerometer measures of at-home daily step counts clinic-based 6MWTs before after regimen. RESULTS: For data collapsed across regimen, correlated significantly total (r=0.466, p=0.033) count (r=0.482, p=0.027). improved (p=0.001) by 40.76±48.58 meters however significant difference neither nor was observed. CONCLUSION: In previous study, improvements patient-reported observed concomitantly (Weinstein 2013). Results this pilot study differed an improvement activity, as measured triaxial accelerometry, not Despite this, accelerometry associated 6MWD. Funding NIH/IRP 1 Z01 CL06006802