Effect of a High Fat Meal on Blood Flow and Endothelial Function during Passive Leg Movement

• DOI: 10.1249/01.mss.0000536893.78590.45
• Publication Date: 2018-06-07T21:47:03Z
• Authors: Morgan M. Monahan; Zakaria Alyousif; Britton C. Scheue...; Timothy R. Rotarius; Christopher R. Si...; Barry W. Scheuermann
• Keywords: Endothelial Dysfunction

Passive leg movement (PLM) leads to a significant increase in femoral artery blood flow (FABF). Recent studies suggest that the FABF during PLM is mediated by bioavailability of nitric oxide (NO) since inhibition NO attenuates response. has been gaining popularity as simple, reliable method for assessing endothelial function. Since consumption high fat meal (HFM) shown induce dysfunction, investigators have used HFM demonstrate therapeutic benefits exercise, anti-inflammatories and anti-oxidants on Consumption response not previously examined but may prove useful determining function healthy diseased populations. PURPOSE: To examine effect consuming single PLM. It was hypothesized would attenuate compared control, consistent with impaired METHODS: Eight (31.8 ± 4.2 yrs, (±SEM)) men (n=5) women (n=3) reported laboratory following 12 h fast no exercise. accomplished using an isokinetic (Biodex) machine which allowed lower move through 90° range motion at 30 cycles/min. Femoral velocities (FABV) were measured continuously baseline (60 s) (120 Doppler ultrasound. calculated arterial diameter baseline. Each subject consumed consisting 90 g total (63 saturated fat), 364 mg cholesterol, 17 carbohydrate, 139 sodium after 2 hrs rest, subjects returned completed second trial. RESULTS: did lead any differences (Pre-HFM, 139.1 21.0 ml/min; Post-HFM, 165.8 44.3 p>0.05). Similarly, peak responses different (p>0.05) between Pre-HFM (301.1 40.8 ml/min) Post-HFM (359.3 73.3 ml/min). CONCLUSION: In contrast our hypothesis comparison previous demonstrating decrease HFM, we observe blunted The reason(s) this discrepancy readily apparent warrants further investigation if be assess health.