Creatine in Type 2 Diabetes

• DOI: 10.1249/mss.0b013e3181fcee7d
• Publication Date: 2010-09-29T10:28:43Z
• Authors: BRUNO GUALANO; VITOR DE SALLES P...; HAMILTON ROSCHEL; GUILHERME GIANNIN...; MANOEL NEVES; ANA LÚCIA DE SÁ P...; MARIA ELIZABETH R...; MARIA ROSÁRIA CUNHA; MARIA CONCEPCIÓN ...; CLAUDIA DA COSTA ...; JÚLIO CÉSAR FERREIRA; ROSA MARIA PEREIRA; PATRÍCIA CHAKUR BRUM; ELOISA BONFÁ; ANTONIO HERBERT L...
• Keywords: Creatine; Lipid Profile

Creatine supplementation improves glucose tolerance in healthy subjects.The aim was to investigate whether creatine has a beneficial effect on glycemic control of type 2 diabetic patients undergoing exercise training.A 12-wk randomized, double-blind, placebo-controlled trial performed. The were allocated receive either (CR) (5 g·d) or placebo (PL) and enrolled an training program. primary outcome glycosylated hemoglobin (HbA1c). Secondary outcomes included the area under curve glucose, insulin, C-peptide insulin sensitivity indexes. Physical capacity, lipid profile, GLUT-4 protein expression translocation also assessed.Twenty-five subjects analyzed (CR: n=13; PL: n=12). HbA1c significantly reduced group when compared with PRE=7.4 ± 0.7, POST=6.4 0.4; PRE=7.5 0.6, POST=7.6 0.7; P=0.004; difference=-1.1%, 95% confidence interval=-1.9% -0.4%). delta concentration lower CR than PL (CR=-7790 4600, PL=2008 7614; P=0.05). presented decreased glycemia at times 0, 30, 60 min during meal test increased translocation. Insulin concentrations, surrogates sensitivity, physical adverse effects comparable between groups.Creatine combined program patients. underlying mechanism seems be related increase recruitment sarcolemma.