Anabolic Steroid Associated to Physical Training Induces Deleterious Cardiac Effects

• DOI: 10.1249/mss.0b013e318217e8b6
• Publication Date: 2011-03-29T05:57:02Z
• Authors: EVERTON CRIVOI DO...; TIAGO FERNANDES; DANIEL KOIKE; NATHAN DANIEL DA ...; KATT COELHO MATTOS; KALEIZU TEODORO ROSA; DIEGO BARRETTI; STÉPHANO FREITAS ...; ROGÉRIO B. WICHI; MARIA CLAUDIA COS...; EDILAMAR MENEZES ...
• Keywords: Cardiac Fibrosis; Nandrolone; Mineralocorticoid

Cardiac aldosterone might be involved in the deleterious effects of nandrolone decanoate (ND) on heart. Therefore, we investigated involvement cardiac aldosterone, by pharmacological block AT1 or mineralocorticoid receptors, hypertrophy and fibrosis.Male Wistar rats were randomized into eight groups (n = 14 per group): Control (C), (ND), trained (T), ND (TND), + losartan (ND L), (TND spironolactone S), S). (10 mg·kg(-1)·wk(-1)) was administered during 10 wk swimming training (five times week). Losartan (20 mg·kg(-1)·d(-1)) drinking water.Cardiac increased 10% using 17% plus (P < 0.05). In both groups, there an increase collagen volumetric fraction (CVF) type III expression The treatment left ventricle-angiotensin-converting enzyme I activity, receptor expression, synthase (CYP11B2), 11-β hydroxysteroid dehydrogenase 2 (11β-HSD2) gene inflammatory markers, TGFβ osteopontin. Both inhibited CVF III. addition, treatments CYP11B2, 11β-HSD2, TGFβ, osteopontin induced treatment.We believe this is first study to show aldosterone. Our results suggest that these may associated Thus, conclude has important role heart ND.