Local Release of Catecholamines From the Hearts of Patients With Tako-Tsubo-Like Left Ventricular Dysfunction

• DOI: 10.1253/circj.72.106
• Publication Date: 2007-12-25T05:49:44Z
• Authors: Teruyoshi Kume; Takahiro Kawamoto; Hiroyuki Okura; Eiji Toyota; Yoji Neishi; Nozomi Watanabe; Akihiro Hayashida; Noriko Okahashi; Yuki Yoshimura; Ken Saito; Shintaro Nezuo; Ryotaro Yamada; Kiyoshi Yoshida
• Keywords: Cardiac Dysfunction; Takotsubo Syndrome

The precise mechanism of tako-tsubo-like left ventricular (LV) dysfunction remains unclear, although recent studies have shown that activation sympathetic tone might be involved. However, local release catecholamines from cardiac efferent neurons in patients with LV poorly understood. purpose this study was to investigate evidence the hearts dysfunction.Five consecutive were studied. After confirming apical ballooning and a normal coronary angiogram, sampling blood for measurement plasma catecholamine levels performed at aortic root (Ao) sinus (CS). In all 5 cases, increased norepinephrine heart documented (597, 4,238, 2,121, 486, 371 pg/ml Ao; 836, 5,719, 3,386, 658, 472 CS, respectively).Increased cause transient dysfunction.