Are Metabolic Factors Associated With Coronary Artery Stenosis on MDCT?

• DOI: 10.1253/circj.cj-08-0416
• Publication Date: 2008-12-25T05:55:49Z
• Authors: Ryoko Mitsutake; Shin-ichiro Miura; Akira Kawamura; Keijiro Saku
• Keywords: Adult; Aged, 80 and over; Blood Glucose; Glycated Hemoglobin; Male; Metabolic Syndrome; Cholesterol, HDL; Coronary Stenosis; Middle Aged; Severity of Illness Index; 03 medical and health sciences; Cross-Sectional Studies; Logistic Models; 0302 clinical medicine; Japan; Predictive Value of Tests; Body Fat Distribution; Humans; Female; Adiponectin; Biomarkers; Aged

The association between metabolic syndrome (MetS) and the severity of coronary artery disease (CAD) as determined by multidetector row computed tomography (MDCT) is unclear.The number of significantly stenosed vessels (VD), coronary artery calcification score, visceral fat area (VFA), subcutaneous fat area (SFA), and abdominal circumference were quantified using MDCT. Plasma levels of metabolic factors were also measured. Plasma levels of adiponectin were negatively correlated with body mass index, diastolic blood pressure, triglycerides, hemoglobin A(1c), fasting glucose, SFA, VFA and waist circumference, and positively correlated with age and high-density lipoprotein-cholesterol (HDL-C). VD in the MetS group was significantly higher than in the non-MetS group. In the 5 groups classified according to the number of metabolic factors, adiponectin was significantly decreased, whereas VD was significantly increased as the number of factors increased. Multivariate logistic regression analysis revealed that the number of VD was most closely correlated with HDL-C (P=0.0014).Of the metabolic factors, lower levels of HDL-C may be most useful for predicting CAD independent of other metabolic markers such as adiponectin, VFA or present medication.