Long-Term Efficacy and Safety Outcomes After Unrestricted Use of Drug-Eluting Stents in Patients With Acute Coronary Syndrome

• DOI: 10.1253/circj.cj-13-1388
• Publication Date: 2014-05-13T23:07:36Z
• Authors: Tetsuma Kawaji; Hiroki Shiomi; Takeshi Morimoto; Toshihiro Tamura; Ryusuke Nishikawa; Mariko Yano; Junichi Tazaki; Masao Imai; Naritatsu Saito; Takeru Makiyama; Satoshi Shizuta; Koh Ono; Takeshi Kimura
• Keywords: Unstable angina; Cumulative incidence

Background: Recent randomized clinical trials have reported favorable outcomes after the use of drug-eluting stents (DES) in patients with acute coronary syndrome (ACS). However, long-term efficacy and safety outcomes, bleeding outcome particular, DES implantation ACS not been thoroughly evaluated a real-world population. Methods Results: We 565 consecutive who underwent an emergency setting between 2004 2011 (ST-segment elevation myocardial infarction [STEMI]: n=269, non-STEMI/unstable angina pectoris: n=296). Mean follow-up period this study was 4.6±2.0 years. The cumulative incidence all-cause death, cardiac infarction, stent thrombosis target-lesion revascularization 6.9%, 4.0%, 2.2%, 1.3% 8.4% at 1 year, 19.6%, 6.7%, 5.6%, 3.0% 13.9% 5 years, respectively. 5-year major events (n=42). Fatal events, however, occurred only 4 patients, even including 2 required resuscitation upon arrival hospital. Of 42 39 were taking dual antiplatelet therapy (DAPT) time bleeding. Conclusions: provided acceptably low fatal population patients. prolonged DAPT seems to be associated implantation. (Circ J 2014; 78: 1628–1635)