Prognostic Relevance of Liver Stiffness Assessed by Transient Elastography in Patients With Acute Decompensated Heart Failure

• DOI: 10.1253/circj.cj-17-1344
• Publication Date: 2018-04-16T22:17:36Z
• Authors: Yuki Saito; Mahoto Kato; Koichi Nagashima; Koyuru Monno; Yoshihiro Aizawa; Yasuo Okumura; Naoki Matsumoto; Mitsuhiko Moriyama; Atsushi Hirayama
• Keywords: Transient elastography; Clinical Significance

Acute decompensated heart failure (ADHF) is often accompanied by liver congestion through increased right atrial pressure (RAP). Liver stiffness (LS) assessed non-invasively using transient elastography related to RAP and in patients with general HF. We investigated the relationship of LS clinical echocardiographic variables outcomes ADHF.Methods Results:The subjects were 105 ADHF admitted hospital between October 2016 June 2017. Patients divided into 2 groups based on median at admission (low <8.8 kPa [n=52] vs. high ≥8.8 [n=53]). Death from cardiovascular disease readmission for HF primary endpoints. Total bilirubin γ-glutamyl transpeptidase levels, MELD-XI score, diameters inferior vena cava ventricle, severity tricuspid regurgitation greater group (all P<0.05). During a (interquartile range) follow-up period 153 (83-231) days, cardiac events occurred 29 (54%) 13 (25%) low (P=0.001). After adjusting that influence organ congestion, was still significantly associated P<0.05).Increased measured reflects elevation, hepatic dysfunction. upon may be useful prognostic marker ADHF.