Global Strain Measured by Three-Dimensional Speckle Tracking Echocardiography Is a Useful Predictor for 10-Year Prognosis After a First ST-Elevation Acute Myocardial Infarction

• DOI: 10.1253/circj.cj-21-0183
• Publication Date: 2021-05-31T22:12:06Z
• Authors: Noriaki Iwahashi; Jin Kirigaya; Masaomi Gohbara; Takeru Abe; Mutsuo Horii; Yohei Hanajima; Noriko Toya; Hironori Takahashi; Yugo Minamimoto; Yuichiro Kimura; Eiichi Akiyama; Kozo Okada; Yasushi Matsuzawa; Nobuhiko Maejima; Kiyoshi Hibi; Masami Kosuge; Toshiaki Ebina; Kouichi Tamura; Kazuo Kimura
• Keywords: Speckle tracking echocardiography; Ventricular remodeling; ST elevation

Three-dimensional (3D) speckle tracking echocardiography (STE) after ST-elevation acute myocardial infarction (STEMI) is associated with left ventricular (LV) remodeling and 1-year prognosis. This study investigated the clinical significance of 3D-STE in predicting long-term prognosis patients STEMI.Methods Results:A total 270 (mean age 64.6 years) first-time STEMI treated reperfusion therapy were enrolled. At 24 h admission, standard 2D 3D full-volume imaging performed, 2D-STE calculated. Patients followed up for a median 119 months (interquartile range: 96-129 months). The primary endpoint was occurrence major adverse cardiac event (MACE: death, heart failure hospitalization), 64 experienced MACEs. Receiver operating characteristic curves Cox hazard multivariate analysis showed that indices stronger predictors MACE compared those 2D-STE. Additionally, 3D-global longitudinal strain (GLS) strongest predictor by circumferential (GCS). Kaplan-Meier curve demonstrated 3D-GLS >-11.0 an independent (log-rank χ2=132.2, P<0.0001). When combined 3D-GCS >-18.3, higher values found to be at extremely high risk MACE.Global measured immediately onset clinically significant 10-year