Involvement of SUMO1 in Alzheimer's disease pathology

• DOI: 10.1254/jpssuppl.92.0_1-p-042
• Publication Date: 2020-03-19T22:08:31Z
• Authors: Shinsuke Matsuzaki; Erin Knocka; Hironori Takamura; Kanayo Satoh; Grace Rooke; Kyung Han; Hong Zhang; Agnieszka Stanisz...; Taiichi Katayama; Ottavio Arancio; Paul E. Fraser

Small ubiquitin-like modifiers (SUMO) are covalently conjugated to target proteins and modulate a growing number of cellular pathways. SUMOs have been strong links tumorgenesis metastasis due regulation nuclear events. More recently, increasing evidence has demonstrated their role in neuronal pathways such as synaptic plasticity memory well several neurodegenerative diseases.