Benzodiazepines and non-benzodiazepine drugs have direct vasorelaxant effects

• DOI: 10.1254/jpssuppl.94.0_1-p2-08
• Publication Date: 2021-03-20T22:08:02Z
• Authors: Satomi Kagota; Kana Morikawa; Hirotake Ishida; Junko Chimoto; Kana Fumoto; Shizuo Yamada,; Kazumasa Shinozuka
• Keywords: Palpitations; Flunitrazepam; Electrical impedance myography; Zopiclone

Benzodiazepines (BDZs) and non-BDZ drugs are associated with side effects such as headaches, dizziness, palpitations. Therefore, we evaluated whether these have direct vasorelaxation onphenylephrine-contracted arteries isolated from Wistar rats using myography. The binding assay of the for GABAAreceptors in rat brain was performed [3H]flunitrazepam an agonist.