15O-H2O PET/CT as a tool for the quantitative assessment of early post-radiotherapy changes of heart perfusion in breast carcinoma patients

• DOI: 10.1259/bjr.20170653
• Publication Date: 2018-02-22T18:56:48Z
• Authors: Agnieszka Żyromska; Bogdan Małkowski; Tomasz Wiśniewski; Karolina Majewska; Joanna Reszke; Roman Makarewicz
• Keywords: Adult; Time Factors; Water; Breast Neoplasms; Heart; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Oxygen Radioisotopes; Coronary Circulation; Positron Emission Tomography Computed Tomography; Humans; Female; Prospective Studies; Aged

Studies examining radiation-induced heart toxicity in breast cancer patients are inconclusive. The aim of this study was to prospectively and quantitatively asses myocardial blood flow (MBF) with, for the first time, 15O-H2O PET/CT as a marker damage irradiated patients.15 receiving intact or chest wall irradiation were included analysis (six with right-sided nine left-sided cancer). They underwent before radiotherapy (RT) 2 8 months after RT. MBF assessed at rest under stress conditions 17 segments distinguished according American Ultrasound Association classification. Regional values derived each coronary artery territories.MBF decreased 53% increased 33% cases RT both patients. Stress testing more sensitive than at-rest testing, demonstrating perfusion supplied by left anterior descending (LAD) [5.41 ± 1.74 vs 4.52 1.82 ml (g*min)-1; p = 0.018], which persisted 6 4.40 1.38 0.032] decrease global [5.14 1.49 4.46 1.73 0.036]. A minimal radiation dose applied LAD correlated changes observed (r -0.57; 0.032). Radiological findings not clinical symptoms toxicity.15O-H2O is safe effective early detection quantitative subclinical post-RT LV main site changes. minimum deposited may be predictor toxicity. Advances knowledge: This time that has been used assess granular description distribution