Comparison of clinical outcome of low-dose and high-dose rabbit antithymocyte globulin induction therapy in renal transplantation: A single-center experience

• DOI: 10.12659/aot.890069
• Publication Date: 2014-06-06T09:12:41Z
• Authors: Dong-dong Chen
• Keywords: Single Center

Background:To explore a better balance between efficacy and complications, we respectively compared the clinical outcome of low-dose high-dose rATG induction therapy with control group in renal transplantations from March 2009 to 2012. Material andMethods:281 kidney transplant recipients were included 3 groups. The (n=39) received 1 mg/kg on first day 0.5 next consecutive days post-transplantation. (n=30) for 6 days. (n=212) no therapy. All patients treated Prednisolone, Mycophenolate mofetil, cyclosporine A, or tacrolimus capsules. Acute rejection rates, function, CMV infection, patient survival, adverse effects reviewed. Results:The acute rate was significantly lower (low-dose 17.9% vs. 35.4%, P=0.03, 16.7% P=0.038). There statistically significant difference 3-year survival graft rates among Renal function early recovery similar group. infection higher than (p=0.037 p=0.002, respectively). associated thrombocytopenia our series, especially Conclusions:Low-dose may be superior transplantation.