Pim-3 is a Critical Risk Factor in Development and Prognosis of Prostate Cancer

• DOI: 10.12659/msm.898223
• Publication Date: 2016-11-09T01:10:35Z
• Authors: Yanchun Qu; Changwen Zhang; E Du; Andi Wang; Yuming Yang; Jianing Guo; Aixiang Wang; Zhihong Zhang; Yong Xu
• Keywords: Aged, 80 and over; Male; 0301 basic medicine; China; Prostatic Hyperplasia; Prostatic Neoplasms; Middle Aged; Protein Serine-Threonine Kinases; Prognosis; 3. Good health; 03 medical and health sciences; Clinical Research; Risk Factors; Case-Control Studies; Cell Line, Tumor; Proto-Oncogene Proteins; Biomarkers, Tumor; Humans; RNA, Messenger; Aged

BACKGROUND Pim-3 kinase is a highly homologous serine/threonine that overexpressed in hematological malignancies and solid tumors. Few studies have been conducted to define the role of tumors, especially prostate cancer. The aim this study was development prognosis MATERIAL AND METHODS We collected specimens from 160 patients with cancer, as well 100 benign prostatic hyperplasia. Realtime polymerase chain reaction used for assessment expression at RNA level Western blot quantify protein synthesis 3 different cell lines. RESULTS found mRNA cancer tissue significantly higher than hyperplasia (p<0.05). Accordingly, lines also control cells. In addition, status associated pathological parameters such pre-surgery specific antigen, Gleason score, stage, lymphoid metastasis. High decreased survival rate after surgery. CONCLUSIONS an important risk factor cancer; we are first team report valuable biomarker Chinese.