Clinical Significance of Transcription Factor 7 (TCF7) as a Prognostic Factor in Gastric Cancer

• DOI: 10.12659/msm.913913
• Publication Date: 2019-05-28T05:14:12Z
• Authors: Xiaoguang Xu; Zhaoxia Liu; Feng Tian; Jian Xu; Yimin Chen
• Keywords: Clinical Significance; Factor (programming language)

BACKGROUND Transcription factor 7 (TCF7) plays an essential role in Wnt signaling by interacting with ß-catenin. Emerging evidence demonstrates that overexpression of TCF7 promotes progression or correlates poor several types cancers, but the functions gastric cancer (GC) have not been revealed. MATERIAL AND METHODS A total 168 patients GC who underwent radical surgeries were collected and regarded as test cohort. The expression was detected immunohistochemistry. Moreover, mRNA levels 11 pairs adjacent tissues quantitative real-time PCR (qRT-PCR). correlations between clinicopathological factors evaluated chi-square test, prognostic value investigated univariate analysis multivariate analysis. RESULTS significantly higher than corresponding tumor tissues. low high accounted for 76.79% (129/168) 23.21% (39/168), respectively. In our experiments, associated positive lymphatic invasion (P=0.022) metastasis (P<0.001). correlated survival rates (P=0.012) confirmed independent (HR=1.92, 95%CI =1.06-3.47, P=0.031) CONCLUSIONS is GC. detection could help stratify risk guide precise treatment.