Coexisting nephrotic syndromes influences in st elevation myocardial infarction patient and chronic limb-threatening ischemia patient: is there any correlation?

• DOI: 10.12688/f1000research.134021.2
• Publication Date: 2025-03-31T17:16:36Z
• Authors: Iwan Dakota; Taofan Taofan; Suci Indriani; Jonathan Edbert A...; Mikhael Asaf; Swastya Dwi Putra; Suko Adiarto; Renan Sukmawan
• Keywords: 0301 basic medicine; 0302 clinical medicine; Clinical Practice Article

<ns3:p>Background ST-elevation myocardial infarction (STEMI) and chronic limb-threatening ischemia (CLTI) are severe cardiovascular emergencies requiring urgent intervention. Nephrotic syndrome (NS) increases the risk of arterial thromboembolism (ATE), but its exact contribution remains underrecognized. Case illustration We present three cases young adults with NS who developed ATE. The first patient had anterior STEMI high thrombus burden no significant atherosclerosis, suggesting a thromboembolic event. second patient, diagnosed CLTI, extensive thrombotic occlusions from infrarenal aorta to bilateral superficial femoral arteries without atherosclerotic plaques, reinforcing mechanism. He declined revascularization was treated medical therapy, achieving symptom relief. third CLTI in external iliac arteries, accompanied by prominent plaque calcification, an contribution. underwent percutaneous transluminal angioplasty favorable outcomes. Conclusion predisposes patients ATE via hypercoagulability and, some cases, atherosclerosis. Cardiovascular screening should be prioritized high-risk patients, preventive measures, including thromboprophylaxis lipid management, considered. Treatment individualized based on predominant mechanism, deferred stenting multidisciplinary approach for CLTI. Long-term follow-up is essential prevent recurrence.</ns3:p>