Role of CXCL13 in the formation of the meningeal tertiary lymphoid organ in multiple sclerosis

• DOI: 10.12688/f1000research.14556.1
• Publication Date: 2018-04-27T11:45:05Z
• Authors: Ana C. Londoño; Carlos A. Mora
• Keywords: CXCL13; Encephalomyelitis

<ns4:p>Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization peripheral immune cells involved in activity disease cascade. However, their spectrum action intrathecal space brain tissue is limited, taking into consideration persistence oligoclonal bands variation clones lymphoid throughout span. In animal models experimental autoimmune encephalomyelitis, a blockage CXCL13 has resulted modification course it could work as potential complementary therapeutic strategy MS order to postpone progression. The development alternatives ability reduce inflammatory meningeal tertiary organ ameliorate neurodegeneration mandatory.</ns4:p>