Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

• DOI: 10.12688/wellcomeopenres.15538.1
• Publication Date: 2019-11-25T15:35:09Z
• Authors: Tina Habota; Anca-Larisa Sandu; Gordon D. Waiter; Christopher J. Mc...; J. Douglas Steele; Jennifer A. Macfa...; Heather C. Whalley; Ruth Valentine; Dawn Younie; Nichola Crouch; Emma L. Hawkins; Yoriko Hirose; Liana Romaniuk; Keith Milburn; Gordon Buchan; Tessa Coupar; Mairi Stirling; Baljit Jagpal; Beverly MacLennan; Lucasz Priba; Mathew A. Harris; Jonathan D. Hafferty; Mark J. Adams; Archie I. Campbell; Donald J. MacIntyre; Alison Pattie; Lee Murphy; Rebecca M. Reynolds; Rebecca Elliot; Ian S. Penton-Voak; Marcus R. Munafò; Kathryn L. Evans; Jonathan R. Seckl; Joanna M. Wardlaw; Stephen M. Lawrie; Christopher S. Haley; David J. Porteous; Ian J. Deary; Alison D. Murray; Andrew M. McIntosh
• Keywords: Depression; Longitudinal Study

STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL to subtype major depressive disorder (MDD) basis its aetiology, using detailed clinical, cognitive, brain imaging assessments. GS:SFHS provides an important opportunity complex gene-environment interactions, incorporating linkage existing datasets inclusion early-life variables for two longitudinal birth cohorts. Specifically, data collection in included: socio-economic lifestyle variables; physical measures; questionnaire that assesses resilience, adversity, personality, psychological health, lifetime history mood disorder; laboratory samples; cognitive tests; magnetic resonance imaging. Some were first assessed at baseline assessment between 2006-2011, thus providing measures depression resilience. Similarly, routine NHS are linked data, further opportunities analysis. Recruitment has been completed we consented tested 1,188 participants.