Effects of Pro-Hyp, a Collagen Hydrolysate-Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis

• DOI: 10.1271/bbb.100193
• Publication Date: 2010-10-07T05:20:17Z
• Authors: Hiroki OHARA; Hiroyuki IIDA; Kyoko ITO; Yasuo TAKEUCHI; Yoshihiro NOMURA
• Keywords: Hydroxyproline; Type II collagen

Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration hydrolysates increased the amount proteoglycans epiphyses. also reduced morphological changes associated with osteoarthritic cartilage destruction knee joint. The results suggest that have therapeutic potential for treatment osteoarthritis.