Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated fromPiper longumon Melanin Production in B16 Mouse Melanoma Cells

• DOI: 10.1271/bbb.100221
• Publication Date: 2010-07-07T02:30:16Z
• Authors: Osamu OHNO; Taeko WATABE; Kazuhiko NAKAMURA; Masaru KAWAGOSHI; Nobuo UOTSU; Tomohiro CHIBA; Masayoshi YAMADA; Kohji YAMAGUCHI; Kaoru YAMADA; Kenji MIYAMOTO; Daisuke UEMURA
• Keywords: Skin whitening; Melanocyte; Melanocyte-stimulating hormone

An EtOH extract of fruits Piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led the isolation prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These crude P. may have suppressive effects pigmentation by skin.