Apoptosis induced by Picolinic Acid-related Compounds in HL-60 Cells

• DOI: 10.1271/bbb.65.2337
• Publication Date: 2002-09-06T09:48:33Z
• Authors: Shin OGATA; Kazuko INOUE; Keiko IWATA; Katsuzumi OKUMURA; Hiroshi TAGUCHI
• Keywords: Picolinic acid

We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also HL-60 These results suggest pyridine substituted with groups the consequent change of resonance structure may an important role induction apoptosis.