Effect of Systemic Glucocorticoids on Mortality or Mechanical Ventilation in Patients With COVID-19

• DOI: 10.12788/jhm.3497
• Publication Date: 2020-07-22T10:10:31Z
• Authors: Marla J Keller; Elizabeth A Kitsis; Shitij Arora; Jen-Ting Chen; Shivani Agarwal; Michael J Ross; Yaron Tomer; William Southern
• Keywords: Adult; Aged, 80 and over; Male; 2. Zero hunger; Adolescent; Pneumonia, Viral; COVID-19; Infant; Comorbidity; Middle Aged; Body Mass Index; 3. Good health; Betacoronavirus; C-Reactive Protein; Child, Preschool; Humans; Female; Child; Coronavirus Infections; Glucocorticoids; Pandemics; Aged

The efficacy of glucocorticoids in COVID-19 is unclear. This study was designed to determine whether systemic glucocorticoid treatment patients associated with reduced mortality or mechanical ventilation. observational included 1,806 hospitalized patients; 140 were treated within 48 hours admission. Early use not However, initial C-reactive protein (CRP) ≥20 mg/dL significantly risk ventilation (odds ratio, 0.23; 95% CI, 0.08- 0.70), while CRP <10 increased (OR, 2.64; 1.39-5.03). Whether changes high low needs prospective, randomized clinical trials. Journal Hospital Medicine 2020;15:XXX-XXX. © 2020 Society