ApoE genotype, past adult lead exposure, and neurobehavioral function.

• DOI: 10.1289/ehp.02110501
• Publication Date: 2010-09-14T19:23:05Z
• Authors: Walter F Stewart; Brian S Schwartz; David Simon; Karl Kelsey; Andrew C Todd
• Keywords: Apolipoprotein E

Our objective in this study was to determine if the known relation between tibia bone lead levels and neurobehavioral test scores are influenced by apolipoprotein E (ApoE) genotype. We collected data on 20 tests 529 former organolead workers who had an average of 16 years since last occupational exposure lead. used linear regression model relations each lead, a binary variable for ApoE genotype (i.e., at least one Epsilon4 allele vs. none), interaction term At time testing, were 57.6 age; 82% younger than 65 years. In analysis, we observed statistically significant borderline coefficient alone. Coefficients negative 19 models. This indicates that slope more individuals with those did not have allele. Four coefficients (digit symbol, Purdue pegboard assembly, pegboard-dominant hand, complex reaction time); another three remaining (symbol digit, trail-making A, Stroop) p < 0.10). suggests may vary susceptibility long-term effects central nervous system (CNS). particular, persistent CNS effect be toxic ApoE-Epsilon4