Association between Local Traffic-Generated Air Pollution and Preeclampsia and Preterm Delivery in the South Coast Air Basin of California

• DOI: 10.1289/ehp.0800334
• Publication Date: 2009-06-24T13:00:21Z
• Authors: Jun Wu; Cizao Ren; Ralph J. Delfino; Judith Chung; Michelle Wilhelm; Beate Ritz
• Keywords: Premature birth

Preeclampsia is a major complication of pregnancy that can lead to substantial maternal and perinatal morbidity, mortality, preterm birth. Increasing evidence suggests air pollution adversely affects outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition birth.We effects residential exposure on delivery (PTD).We identified 81,186 singleton birth records from four hospitals (1997-2006) Los Angeles Orange Counties, California (USA). We used line-source dispersion model (CALINE4) estimate individual nitrogen oxides (NO(x)) particulate matter < 2.5 mum aerodynamic diameter (PM(2.5)) across the entire pregnancy. logistic regression exposures preeclampsia, PTD (gestational age 37 weeks), moderate (MPTD; gestational 35 very (VPTD; 30 weeks).We observed elevated risks for NO(x) PM(2.5). The risk increased 33% [odds ratio (OR) = 1.33; 95% confidence interval (CI), 1.18-1.49] 42% (OR 1.42; CI, 1.26-1.59) highest PM(2.5) quartiles, respectively. VPTD 128% 2.28; 2.15-2.42) 81% 1.81; 1.71-1.92) women respectively.Exposure during increases Southern women. These results provide further associated with adverse reproductive