Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City

• DOI: 10.1289/ehp.0800522
• Publication Date: 2009-06-16T14:14:24Z
• Authors: John D. Meeker; Howard Hu; David E. Cantonwine; Hector Lamadrid-F...; Antonia M. Calafat; Adrienne S. Ettinger; Mauricio Hernande...; Rita Loch-Caruso; Martha María Téll...
• Keywords: Adult; Pregnancy Trimester, Third; Phthalic Acids; 610; 01 natural sciences; Young Adult; Pregnancy; Risk Factors; case–control; Humans; children's health; Mexico; 0105 earth and related environmental sciences; Research; prematurity; Environmental Exposure; 3. Good health; exposure; Maternal Exposure; Case-Control Studies; Premature Birth; epidemiology; Female; pregnancy; environment

Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure environmental contaminants may play a role.We investigated relationship between phthalate birth.Within large Mexican cohort study, we compared third-trimester urinary metabolite concentrations in 30 women who delivered (< 37 weeks gestation) with those controls (> or = gestation).Concentrations most metabolites were similar reported among U.S. females, although present study mono-n-butyl (MBP) higher monobenzyl (MBzP) lower. In crude comparison before correcting for dilution, geometric mean MBP, MBzP, mono(3-carboxylpropyl) phthalate, four di(2-ethyl-hexyl) subsequently preterm. These differences remained, but somewhat lessened, after correction by specific gravity creatinine. multivariate logistic regression analysis adjusted potential confounders, elevated odds having above median level found.We found that is prevalent group pregnant Mexico some phthalates be associated birth.