Global Gene Expression Profiling of a Population Exposed to a Range of Benzene Levels

• DOI: 10.1289/ehp.1002546
• Publication Date: 2010-12-14T14:19:49Z
• Authors: Cliona M. McHale; Luoping Zhang; Qing Lan; Roel Vermeulen; Guilan Li; Alan E. Hubbard; Kristin E. Porter; Reuben Thomas; Christopher J. Po...; Min Shen; Stephen M. Rappaport; Songnian Yin; Martyn T. Smith; Nathaniel Rothman
• Keywords: Adult; Male; 0301 basic medicine; Lymphatic Research; Biomedical and clinical sciences; Lymphoma; Pediatric Cancer; Childhood Leukemia; Oncology and Carcinogenesis; Mononuclear; 610; Toxicology; Medical and Health Sciences; benzene; transcriptomics; Young Adult; 03 medical and health sciences; Rare Diseases; Occupational Exposure; Genetics; Leukocytes; 2.1 Biological and endogenous factors; Humans; human; Cancer; Pediatric; Leukemia; Biomedical and Clinical Sciences; Research; Gene Expression Profiling; Health sciences; Benzene; Hematology; 3. Good health; Environmental sciences; Leukocytes, Mononuclear; biomarker; Female; microarray; Environmental Sciences

Benzene, an established cause of acute myeloid leukemia (AML), may also one or more lymphoid malignancies in humans. Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels benzene through transcriptomic analyses blood cells from a small number occupationally exposed workers.