Association of Urinary Concentrations of Bisphenol A and Phthalate Metabolites with Risk of Type 2 Diabetes: A Prospective Investigation in the Nurses’ Health Study (NHS) and NHSII Cohorts

• DOI: 10.1289/ehp.1307201
• Publication Date: 2014-03-14T16:11:32Z
• Authors: Qi Sun; Marilyn C. Cornelis; Mary K. Townsend; Deirdre K. Tobias; A. Heather Eliassen; Adrian A. Franke; Russ Hauser; Frank B. Hu
• Keywords: Quartile; Benzhydryl compounds

Prospective evidence regarding associations for exposures to bisphenol A (BPA) and phthalates with type 2 diabetes (T2D) is lacking.We prospectively examined urinary concentrations of BPA phthalate metabolites T2D risk.We measured eight major among 971 incident case-control pairs from the Nurses' Health Study (NHS) (mean age, 65.6 years) NHSII 45.6 years).In NHSII, levels were not associated in multivariate-adjusted analysis until body mass index was adjusted: odds ratio (OR) comparing extreme quartiles increased 1.40 (95% CI: 0.91, 2.15) 2.08 1.17, 3.69; p(trend) = 0.02) such an adjustment. In contrast, NHS (OR 0.81; 95% 0.48, 1.38; 0.45). Likewise, total 2.14; 1.19, 3.85; 0.02), but 0.87; 0.49, 1.53; 0.29). Summed butyl or di-(2-ethylhexyl) significantly only NHSII; ORs 3.16 1.68, 5.95; 0.0002) 1.91 1.04, 3.49; 0.20), respectively.These results suggest that may be risk middle-aged, older, women. The divergent findings between two cohorts might explained by menopausal status simply chance. Clearly, these need interpreted caution should replicated future studies, ideally multiple urine samples collected improve measurement short half-lives.