Urinary Trivalent Methylated Arsenic Species in a Population Chronically Exposed to Inorganic Arsenic

• DOI: 10.1289/ehp.7519
• Publication Date: 2004-11-22T19:43:18Z
• Authors: Olga L. Valenzuela; Victor H. Borja-A...; Gonzalo G. Garcia...; Martha B. Cruz-Go...; Eliud A. Garcia-M...; Emma S. Calderon-...; Luz M. Del Razo
• Keywords: Adult; Male; 0301 basic medicine; Adolescent; Research; Environmental Exposure; Middle Aged; Methylation; Risk Assessment; 01 natural sciences; Arsenicals; 6. Clean water; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; Water Supply; 13. Climate action; Neoplasms; Arsenic Poisoning; Cacodylic Acid; Humans; Female; Mexico; 0105 earth and related environmental sciences

Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms cancer and noncancerous diseases. Metabolic conversions iAs that yield highly toxic genotoxic methylarsonite (MAsIII) dimethylarsinite (DMAsIII) may play a significant role in determining the extent character cancer-promoting effects exposure. In this study we examined relationship between urinary profiles MAsIII DMAsIII skin lesion markers toxicity individuals exposed drinking water. The subjects were recruited among residents an endemic region central Mexico. Drinking-water reservoirs are heavily contaminated iAs. Previous studies carried out local populations have found incidence pathologies, primarily lesions, characteristic arseniasis. goal was investigate for trivalent pentavalent As metabolites both high- low-iAs-exposed subjects. Notably, methylated arsenicals detected 98% analyzed urine samples. On average, major metabolite, DMAsIII, represented 49% total As, followed by DMAsV (23.7%), iAsV (8.6%), iAsIII (8.5%), (7.4%), MAsV (2.8%). More important, average concentration significantly higher lesions compared those who drank iAs-contaminated water but had no lesions. These data suggest levels MAsIII, most species identified iAs, serve as indicator identify susceptibility