Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers

• DOI: 10.1289/ehp.8288
• Publication Date: 2005-09-29T18:21:40Z
• Authors: Yi-Chun E. Chao; Lawrence L. Kupper; Berrin Serdar; Peter P. Egeghy; Stephen M. Rappaport; Leena A. Nylander...
• Keywords: Jet fuel; Inhalation exposure

Jet propulsion fuel 8 (JP-8) is the major jet used worldwide and has been recognized as a source of chemical exposure, both inhalation dermal, for fuel-cell maintenance workers. We investigated contributions dermal exposure to JP-8 total body dose U.S. Air Force workers using naphthalene surrogate exposure. Dermal, breathing zone, exhaled breath measurements were obtained tape-strip sampling, passive monitoring, glass bulbs, respectively. Levels urinary 1- 2-naphthols determined in urine samples biomarkers Multiple linear regression analyses conducted investigate relative JP-8, demographic work-related covariates, levels naphthols. Our results show that smoking significantly contributed 1-naphthol levels. The contribution was associated with 2-naphthol but not among who wore supplied-air respirators. conclude contributes systemic affects metabolites. Future work on xenobiotic metabolism toxicokinetic studies are warranted order gain additional knowledge skin