The Effect of Inhaled Chromium on Different Exhaled Breath Condensate Biomarkers among Chrome-Plating Workers

• DOI: 10.1289/ehp.8506
• Publication Date: 2005-12-08T21:03:56Z
• Authors: Andrea Caglieri; Matteo Goldoni; Olga Acampa; Roberta Andreoli; Maria Vittoria Ve...; Massimo Corradi; Pietro Apostoli; Antonio Mutti
• Keywords: Chronic bronchitis; International agency; Inhalation exposure

Chromium is corrosive, cytotoxic, and carcinogenic for humans can induce acute chronic lung tissue toxicity. The aim of this study was to investigate Cr levels in exhaled breath condensate (EBC) workers exposed Cr(VI) assess their relationship with biochemical changes the airways by analyzing EBC biomarkers oxidative stress, namely, hydrogen peroxide (H2O2) malondialdehyde (MDA). samples were collected from 24 chrome-plating employed a plant both before after Friday work shift on following Monday. Cr-EBC increased beginning (5.3 μg/L) end (6.4 but considerably lower Monday morning (2.8 μg/L). A similar trend observed H2O2-EBC (which 0.36 μM 0.59 0.19 morning) MDA-EBC 8.2 nM 9.7 6.6 Monday). correlated those (r = 0.54, p < 0.01) 0.59, 0.01), as well urinary 0.25, 0.05). results demonstrate that suitable matrix be used free radical production sampling epithelial-lining fluid Cr(VI).