Coarse Particulate Matter (PM 2.5–10 ) Affects Heart Rate Variability, Blood Lipids, and Circulating Eosinophils in Adults with Asthma

• DOI: 10.1289/ehp.9499
• Publication Date: 2007-01-18T19:44:16Z
• Authors: Karin Yeatts; Erik Svendsen; John Creason; Neil Alexis; Margaret Herbst; James Scott; Lawrence Kupper; Ronald Williams; Lucas Neas; Wayne Cascio; Robert B. Devlin; David B. Peden
• Keywords: Adult; Male; Coarse PM; Systemic inflammation; Research; Inflammatory markers; 610; Lipids; 01 natural sciences; Asthma; 3. Good health; Eosinophils; Heart Rate; 11. Sustainability; Linear Models; North Carolina; Humans; Female; Particulate Matter; Heart rate variability; 0105 earth and related environmental sciences

We investigated whether markers of airway and systemic inflammation, as well heart rate variability (HRV) in asthmatics, change response to fluctuations ambient particulate matter (PM) the coarse [PM with aerodynamic diameter 2.5-10 microm (PM(2.5-10))] fine (PM(2.5)) size range.Twelve adult living within a 30-mile radius an atmospheric monitoring site Chapel Hill, North Carolina, were followed over 12-week period. Daily PM(2.5-10) PM(2.5) concentrations measured separately for each 24-hr Each subject had nine clinic visits, at which spirometric measures peripheral blood samples analysis lipids, inflammatory cells, coagulation-associated proteins obtained. also assessed HRV [SDNN24HR (standard deviation all normal-to-normal intervals recording), ASDNN5 (mean standard 5-min segments recording)] four consecutive ambulatory electrocardiogram measurements. Linear mixed models spatial covariance matrix structure 1-day lag used assess potential associations between PM levels cardiopulmonary end points.For 1-microg/m(3) increase PM, SDNN24HR, decreased 3.36% (p = 0.02), 0.77%, 0.05) respectively. With circulating eosinophils increased 0.16% 0.01), triglycerides 4.8% very low-density lipoprotein 1.15% 0.01). No significant found none lung function.These data suggest that small temporal increases are sufficient affect important lipid parameters adults asthma. Coarse may have underappreciated health effects susceptible populations.