The relationship between environmental monitoring and biological markers in exposure assessment.

• DOI: 10.1289/ehp.95103s349
• Publication Date: 2011-05-20T15:22:28Z
• Authors: S M Rappaport; E Symanski; J W Yager; L L Kupper
• Keywords: Inhalation exposure

The poor quality of traditional assessments exposure has encouraged epidemiologists to explore biological monitoring in studies chronic diseases. Yet, despite theoretical advantages, biomarkers have not been widely used such applications. This article compares the general utility a biomarker with that measurement per se. Points are illustrated longitudinal study boat workers which levels styrene breathing zone and exhaled air were compared sister chromatid exchanges (SCEs) peripheral lymphocytes. First, linear relationship is explored between personal cohort. A good fit straight-line reflected by correlation coefficient close 1, as observed (r2 = 0.83), suggests kinetics, appropriate route was measured monitoring, small interindividual differences, adequate sample sizes, specific biomarker. However, coefficient, SCEs 0.11), indicates either kinetics nonlinear or more complex issues involved one these factors. Second, environmental biologic measurements for use independent variables establishing health effect. If ratio within-person between-person components variance variable large, then significant attenuation results when estimating slope line.(ABSTRACT TRUNCATED AT 250 WORDS)