A Paraneoplastic Syndrome to Remember: A Case of Disseminated Intravascular Coagulation in Lung Cancer

• DOI: 10.12890/2019_001134
• Publication Date: 2019-06-28T04:36:50Z
• Authors: Rita de Sousa Gam...; Rodolfo Gomes; Vanda Jorge; Bárbara Sousa Picado; Fernando Martos G...; José Lomelino Araújo
• Keywords: R; Articles; la Medicina interna; Disseminated intravascular coagulation; la Medicina sperimentale); 3. Good health; lung cancer; 03 medical and health sciences; 0302 clinical medicine; la medicina basata sull'evidenza; Medicine; 616 Malattie (classificare qui la Clinica medica; intracerebral bleeding

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by the widespread activation of coagulation. It can present as an acute life-threatening emergency or as a chronic process. Mortality is highly dependent on the reversibility of the aetiology and degree of coagulation impairment, so treatment of the underlying cause is vital. The authors present the case of a 57-year-old man whose inaugural presentation of lung cancer was chronic DIC, characterized by three thrombotic events, followed by acute DIC, culminating in death. Metastatic lung cancer was diagnosed only after death.Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by systemic intravascular activation of coagulation, originating from and causing damage to the microvasculature, which can present as an acute or chronic condition, manifested by bleeding or thrombotic events.Unexplained thrombotic events should raise suspicion of chronic DIC.Treatment will fail, despite supportive measures, if the cause of the DIC is not identified.