Effects of Electroacupuncture at Zusanli and Baihui on Brain-Derived Neurotrophic Factor and Cyclic AMP Response Element-Binding Protein in the Hippocampal Dentate Gyrus
Male
Brain-Derived Neurotrophic Factor
Brain
Cell Differentiation
Hippocampus
Rats
03 medical and health sciences
Electroacupuncture
0302 clinical medicine
Dentate Gyrus
Animals
Rats, Wistar
Cyclic AMP Response Element-Binding Protein
Muscle, Skeletal
Acupuncture Points
Cell Division
DOI:
10.1292/jvms.09-0527
Publication Date:
2010-07-07T02:30:23Z
AUTHORS (7)
ABSTRACT
Previously, we observed that electroacupuncture (EA) at ST36 (Zusanli) and GV20 (Baihui) enhanced cell proliferation and neuroblast differentiation in the rat dentate gyrus. In this study, we investigated the possible mechanisms of EA in this effect. For this, we applied EA at ST36 and GV20 of Wistar rats (13-week-old) once a day for 3 weeks. Application of EA at these acupoints significantly increased the number of phosphorylated cyclic AMP response element-binding protein (pCREB)-immunoreactive cells in the dentate gyrus. In addition, EA significantly increased the levels of brain-derived neurotrophic factor (BDNF) and pCREB protein in the dentate gyrus. The administration of K252a, an inhibitor of BDNF receptor, significantly reduced cell proliferation in the subgranular zone of dentate gyrus. These results suggest that EA significantly increased neuroblast plasticity via pCREB and BDNF activation in the dentate gyrus.
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