Effects of Electroacupuncture at Zusanli and Baihui on Brain-Derived Neurotrophic Factor and Cyclic AMP Response Element-Binding Protein in the Hippocampal Dentate Gyrus

• DOI: 10.1292/jvms.09-0527
• Publication Date: 2010-07-07T02:30:23Z
• Authors: In Koo HWANG; Jin Young CHUNG; Dae Young YOO; Sun Shin YI; Hwa Young YOUN; Je Kyung SEONG; Yeo Sung YOON
• Keywords: Zusanli; Subgranular zone

Previously, we observed that electroacupuncture (EA) at ST36 (Zusanli) and GV20 (Baihui) enhanced cell proliferation neuroblast differentiation in the rat dentate gyrus. In this study, investigated possible mechanisms of EA effect. For this, applied Wistar rats (13-week-old) once a day for 3 weeks. Application these acupoints significantly increased number phosphorylated cyclic AMP response element-binding protein (pCREB)-immunoreactive cells addition, levels brain-derived neurotrophic factor (BDNF) pCREB The administration K252a, an inhibitor BDNF receptor, reduced subgranular zone These results suggest plasticity via activation