Early-Onset Podocyte Injury and Glomerular Sclerosis in Osborne-Mendel Rats

• DOI: 10.1292/jvms.10-0094
• Publication Date: 2010-05-21T02:30:20Z
• Authors: Kyohei YASUNO; Shoko ISHIHARA; Rio SAITO; Makoto ISHIKAWA; Takashi KATO; Ryosuke KOBAYASHI; Tomoshige BABA; Kazuya KAWANO; Kikumi OGIHARA; Junichi KAMIIE; Kinji SHIROTA
• Keywords: Glomerulosclerosis; Albuminuria; Podocin; Desmin

Progressive glomerular injury associated with early-onset proteinuria was investigated in male Osborne-Mendel (OM) rats aged 5 to 20 weeks. Age-matched Fischer 344 (F344) were used for comparison. OM developed mild hypertension and selective (albuminuria) from weeks of age, non-selective 7 age. Light microscopy kidney revealed hyaline droplets the podocyte at age vacuolation podocytes adhesion capillary loop Bowman's capsule Segmental glomerulosclerosis 15 global sclerosis appeared Desmin, a marker podocye injury, expressed 10 intensity expression increased Ultrastructurally, damage such as effacement foot processes, decreasing number filtration slits, rearrangement actin cytoskeleton observed rat. Glomerular volume consistently higher than age-matched F344 rats. The WT-1-positive vimentin-positive area lower decreased These findings suggest that glomerulonephropathy is hypertrophy, progressive podocytopathy, reduction area. Renal development more