Unsuccessful Cyclosporine plus Prednisolone Therapy for Autoimmune Meningoencephalitis in Three Dogs

• DOI: 10.1292/jvms.12-0503
• Publication Date: 2013-08-12T23:03:13Z
• Authors: Dong-In JUNG; Hee-Chun LEE; Jeongim HA; Hae-Won JUNG; Joon-Hyeok JEON; Jong-Hyun MOON; Jae-Hoon LEE; Na-Hyun KIM; Jung-Hyang SUR; Byeong-Teck KANG; Kyu-Woan CHO
• Keywords: Prednisolone; Paresis; Etiology

A 4-year-old female Maltese (case 1), a 9-year-old castrated male shih tzu 2) and 2-year-old Pomeranian 3) presented with neurological signs, such as head tilt, ataxia, circling paresis. The three cases were tentatively diagnosed having meningoencephalitis of unknown etiology based on computed tomography scan cerebrospinal fluid analysis. All patients managed cyclosporine plus prednisolone therapy. survival times the 170, 70 21 days, respectively. After died, we performed necropsy histopathological examination for definitive diagnosis. Based necropsy, immunohistochemical examinations, 1, 2 3 definitely necrotizing meningoencephalitis, leukoencephalitis granulomatous This case report demonstrated clinical findings, brain CT characteristics features NME, NLE GME in dogs discussed reason relatively short under