<i>Notch2</i> Transduction by Feline Leukemia Virus in a Naturally Infected Cat

• DOI: 10.1292/jvms.13-0344
• Publication Date: 2013-12-08T23:07:42Z
• Authors: Shinya WATANABE; Jumpei ITO; Takuya BABA; Takahiro HIRATSUKA; Kyohei KUSE; Haruyo OCHI; Yukari ANAI; Masaharu HISASUE; Hajime TSUJIMOTO; Kazuo NISHIGAKI
• Keywords: Feline leukemia virus; Transduction (biophysics)

Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed associated with including lymphoma sarcoma. Here, we report the first natural case feline Notch2 an infected cat multicentric hypercalcemia. We cloned recombinant FeLVs harboring env gene. was able to activate expression a reporter gene, similar what previously reported cats experimental FeLV-induced thymic lymphoma. Our findings suggest that strongly correlates