Effects of a Bacteria-Based Probiotic on Subpopulations of Peripheral Leukocytes and Their Cytokine mRNA Expression in Calves
Clostridium butyricum
TLR5
DOI:
10.1292/jvms.13-0370
Publication Date:
2013-10-16T23:04:05Z
AUTHORS (6)
ABSTRACT
Eight Holstein calves (10 ± 3 weeks) were used to examine the interaction between a bacteria-based probiotic agent (probiotic) and function of peripheral blood mononuclear cells (PBMCs). The probiotic, consisting Lactobacillus plantarum, Enterococcus faecium Clostridium butyricum, was administered orally at 3.0 g/100 kg body weight once daily for 5 consecutive days. Calves given vehicle alone with no served as control. In treatment group, increases in numbers CD282(+) (TLR2) monocytes, CD3(+) T CD4(+), CD8(+) WC1(+) γδ cell subsets noted on day 7 post-placement compared predose control group. Expression interleukin (IL)-6, interferon-gamma (INF-γ) tumor necrosis factor-alpha (TNF-α) elevated leukocytes days 14. These results suggest that healthy may be stimulated via gastrointestinal microbiota, which increased by oral treatment, overall stability rumen bacterial flora. 5-day repeated administration enhance cellular immune weaned calves.
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