The Relationship between Clinicopathological Features and Expression of Epithelial and Mesenchymal Markers in Spontaneous Canine Mammary Gland Tumors

• DOI: 10.1292/jvms.14-0104
• Publication Date: 2014-06-16T13:41:54Z
• Authors: Kota YOSHIDA; Saori YOSHIDA; Nan CHOISUNIRACHON; Tomochika SAITO; Kaori MATSUMOTO; Kohei SAEKI; Manabu MOCHIZUKI; Ryohei NISHIMURA; Nobuo SASAKI; Takayuki NAKAGAWA
• Keywords: Univariate analysis

It is known that epithelial mesenchymal transition (EMT) contributes to the acquisition of malignant property in human cancers. However, role EMT canine tumors remains be elucidated. To evaluate correlation between expression levels protein markers involved and clinicopathological characteristics mammary gland tumors, immunohistochemistry using antibodies against ZO-1, E-cadherin, vimentin, N-cadherin fibronectin was performed on 119 clinical tissue samples. Consequently, loss ZO-1 gain vimentin were more frequently observed than benign tumors. there no among these molecules. Univariate multivariate analysis identified E-cadherin independently had a low one-year survival rate (adjusted odds ratio: 2.3, P=0.02). These results suggested might relate malignancy, additionally, strongly correlated with behavior