Estimation of Glomerular Filtration Rate in Cynomolgus Monkeys (<i>Macaca fascicularis</i>)

• DOI: 10.1292/jvms.14-0218
• Publication Date: 2014-07-06T23:11:49Z
• Authors: Ryosuke IWAMA; Tsubasa SATO; Ken SAKURAI; Kiyoshi TAKASUNA; Toshihiro ICHIJO; Kazuhisa FURUHAMA; Hiroshi SATOH
• Keywords: Iodixanol; Filtration fraction; Blood collection; Basal (medicine)

To estimate the glomerular filtration rate (GFR) in cynomolgus monkeys (Macaca fascicularis), a three-blood-sample method using iodixanol was assessed comparison with conventional multisample strategy inulin. Iodixanol and inulin were coadministered intravenously 40 mg I/kg 50 mg/kg, respectively, to male monkeys, followed by blood collection 60, 90 120 min later. A close correlation (r=0.96) noted between GFR values estimated both methods. In clinically healthy basal determined be 3.06 ± 0.50 ml/min/kg. This is first report, suggesting that serum clearance of ready-to-use tool for screening although it necessary perform more longitudinal study animals reduced renal function.