The oncolytic effects of reovirus in canine solid tumor cell lines

• DOI: 10.1292/jvms.14-0570
• Publication Date: 2015-01-15T22:09:51Z
• Authors: Masaya IGASE; Chung Chew HWANG; Matt COFFEY; Masaru OKUDA; Shunsuke NOGUCHI; Takuya MIZUNO
• Keywords: Canine Lymphoma

Oncolytic virotherapy is a new strategy for cancer treatment humans and dogs. Reovirus has been proven to be potent oncolytic virus in human medicine. Our laboratory previously reported that canine mast cell tumor lymphoma were susceptible reovirus. In this study, solid lines (mammary gland tumor, osteosarcoma malignant melanoma) tested determine their susceptibility towards We demonstrated reovirus induces more than 50% death three mammary tumors one melanoma line. The reovirus-induced occurred via the activation of caspase 3. Ras shown important mechanisms reovirus-susceptibility cancers. However, was not related lines, which similar reports lymphoma. results study highly suggest are also potential candidates therapy veterinary oncology.