The oncolytic effects of reovirus in canine solid tumor cell lines
0301 basic medicine
2. Zero hunger
Mammary Neoplasms, Animal
04 agricultural and veterinary sciences
Reoviridae
Virus Replication
3. Good health
Gene Expression Regulation, Neoplastic
0403 veterinary science
Oncolytic Viruses
03 medical and health sciences
Dogs
Cell Line, Tumor
Internal Medicine
Animals
Female
Dog Diseases
Poly(ADP-ribose) Polymerases
Melanoma
Cell Proliferation
DOI:
10.1292/jvms.14-0570
Publication Date:
2015-01-15T22:09:51Z
AUTHORS (6)
ABSTRACT
Oncolytic virotherapy is a new strategy for cancer treatment for humans and dogs. Reovirus has been proven to be a potent oncolytic virus in human medicine. Our laboratory has previously reported that canine mast cell tumor and canine lymphoma were susceptible to reovirus. In this study, canine solid tumor cell lines (mammary gland tumor, osteosarcoma and malignant melanoma) were tested to determine their susceptibility towards reovirus. We demonstrated that reovirus induces more than 50% cell death in three canine mammary gland tumors and one canine malignant melanoma cell line. The reovirus-induced cell death occurred via the activation of caspase 3. Ras activation has been shown to be one of the important mechanisms of reovirus-susceptibility in human cancers. However, Ras activation was not related to the reovirus-susceptibility in canine solid tumor cell lines, which was similar to reports in canine mast cell tumor and canine lymphoma. The results of this study highly suggest that canine mammary gland tumor and canine malignant melanoma are also potential candidates for reovirus therapy in veterinary oncology.
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