Bimodal immunoglobulin A gammopathy in a cat with feline myeloma-related disorders

• DOI: 10.1292/jvms.15-0156
• Publication Date: 2015-12-03T22:04:58Z
• Authors: Masaya IGASE; Takako SHIMOKAWA ...; Satoshi KAMBAYASHI; Yumiko SHIMOYAMA; Hiroko HIRAOKA; Yumi HIRATA; Miki IWATA; Kenji BABA; Takuya MIZUNO; Masaru OKUDA
• Keywords: 0403 veterinary science; 2. Zero hunger; Internal Medicine; Cats; Paraproteinemias; Animals; Female; 04 agricultural and veterinary sciences; Cat Diseases; Multiple Myeloma; Immunoglobulin A; 3. Good health

A 10-year-old female spayed mixed breed cat with a subcutaneous mass on the right hind limb was revealed with bimodal monoclonal gammopathy composed of IgA by immunoelectrophoresis and immunofixation. Approximately 1 month after referral, the cat died due to renal failure. Postmortem immunohistopathologic evaluation of the subcutaneous mass revealed neoplastic cell proliferation of plasma cells and giant myeloma cells. Neoplastic cells were also present in the liver and spleen. These results led to the diagnosis of a rare case of feline myeloma-related disorders with extramedullary plasmacytoma infiltrating in multiple locations. This report emphasizes the necessity to accumulate cases with similar clinicopathologic findings in the future.