Utility of arterial blood gas, CBC, biochemistry and cardiac hormones as evaluation parameters of cardiovascular disease in nonhuman primates

• DOI: 10.1292/jvms.18-0124
• Publication Date: 2018-06-10T22:16:09Z
• Authors: Shunya NAKAYAMA; Hiroshi KOIE; Kiichi KANAYAMA; Yuko KATAKAI; Yasuyo ITO-FUJISHIRO; Tadashi SANKAI; Yasuhiro YASUTOMI; Naohide AGEYAMA
• Keywords: Arterial blood

Cardiovascular disease (CVD) has a tremendous impact on the quality of life humans. While experimental animals are valuable to medical research as models human diseases, cardiac systems differ widely across various animal species. Thus, we examined CVD model in cynomolgus monkeys. Laboratory primates precious resources, making it imperative that symptoms diseases and disorders detected early possible. this study comprehensively important indicators monkeys, including arterial blood gas, complete count (CBC), biochemistry hormones. The control group included 20 healthy macaques showing non-abnormal findings screening tests, whereas with valvular cardiomyopathy. An increase red cell distribution width was observed CBC, indicating chronic inflammation related CVD. HCO3 attributed correction acidosis. Furthermore, development supported by significant increases natriuretic peptides. It is suggested these results indicated correlation between Moreover, tests gas non-invasive can be performed more easily than other technical tests. affected change their condition anesthesia surgical invasion. Pay attention proper respond for research. This data may facilitate aid management veterinary care nonhuman primates.