Urinary D-amino acid profiles in cats with chronic kidney disease

• DOI: 10.1292/jvms.24-0023
• Publication Date: 2024-06-06T22:11:00Z
• Authors: Ren KIMURA; Reeko UEDA; Hisashi TSUJIMURA; Takeshi BAN; Atsushi TANAKA
• Keywords: Male; Physiology; Tandem Mass Spectrometry; Creatinine; Case-Control Studies; Cats; Animals; Female; Renal Insufficiency, Chronic; Amino Acids; Cat Diseases; Blood Urea Nitrogen; Chromatography, Liquid

Chronic kidney disease (CKD) is highly prevalent in domestic cats. This study aimed to compare urinary D-amino acid levels between control and CKD-afflicted cats as a novel noninvasive method for assessing CKD. Cats were divided into CKD stage II groups accordance with the International Renal Interest Society guidelines. The DL-amino of analyzed using chiral tandem liquid chromatography-tandem mass spectrometry, their medical records investigated. group had considerably lower concentrations enantiomeric ratios than group. total contents significantly correlated blood parameters (creatinine urea nitrogen). These findings may contribute towards detection